/*  Stylesheet for NLM/NCBI  Journal Publishing 3.0 Preview HTML
    January 2009

    ~~~~~~~~~~~~~~
    National Center for Biotechnology Information (NCBI)
    National Library of Medicine (NLM)
    ~~~~~~~~~~~~~~

This work is in the public domain and may be reproduced, published or
otherwise used without the permission of the National Library of Medicine (NLM).

We request only that the NLM is cited as the source of the work.

Although all reasonable efforts have been taken to ensure the accuracy and
reliability of the software and data, the NLM and the U.S. Government  do
not and cannot warrant the performance or results that may be obtained  by
using this software or data. The NLM and the U.S. Government disclaim all
warranties, express or implied, including warranties of performance,
merchantability or fitness for any particular purpose.

*/


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div { margin-top: 0.5em }

div.front, div.footer { }

.back, .body { font-family: serif }

div.metadata { font-family: sans-serif }
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div.table { display: table }
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div.metadata div.cell {
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div.two-column div.cell {
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div.metadata-group { margin-top: 0.5em;
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div.metadata-group > p, div.metadata-group > div { margin-top: 0.5em }

div.metadata-area * { margin: 0em }

div.metadata-chunk { margin-left: 1em }

div.branding { text-align: center }

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div.footnote { font-size: 90% }

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p.first { margin-top: 0em }

p.verse-line, p.citation { margin-top: 0em; margin-bottom: 0em; margin-left: 2em; text-indent: -2em }

p.address-line { margin-top: 0em; margin-bottom: 0em; margin-left: 2em }

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a:hover { text-decoration: underline }

/* ---------------- End ------------------------------ */


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				    vertical-align: top;
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					border-radius: 5px;
					margin: 3mm;
					box-shadow: 0px 0px 5px 3px rgba(0,0,0, 0.3);
					background: white;
					word-wrap:  break-word;
					font-size: 12pt;
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				.co-default a {
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				.co-fig {
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				.co-inner > div + div,
				.co-inner > li + li{
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				.large-thumb{
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					filter: alpha(opacity=0);
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				.legend, .large-thumb {
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				.legend{
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				    max-width: none;
				    bottom: 42pt;
				    -webkit-box-shadow: 0 0 10px #000;
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				    box-shadow: 0 0 10px #000;
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				    left: 8pt;
				    right: 8pt;
				    top: 8pt;
				    z-index: 7000;
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				.jr-objectbox.help,
				.jr-objectbox.note {
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				.jr-objectbox.about {
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				    max-height: 30em;
				    margin: auto;
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				.jr-objectbox:after {
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				.thidden {
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				    right: 0;
				    -webkit-transform:       translateX(0);
				    -moz-transform:          translateX(0);
				    -ms-transform:           translateX(0);
				    -o-transform:            translateX(0);
				    transform:               translateX(0);
				}


				aside.jr-objectbox .cnt {
				    background: none;
				    margin: 6pt;

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				.jr-objectbox .cnt {
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				.jr-objectbox-close {
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				    left: -8pt;
				    top: -8pt;
				    color: red;
				    background: white;
				    border: 6pt solid rgba(0,0,0,.75);
				    border-radius: 15pt;
				    width: 1.5em;
				    height: 1.5em;
				    line-height: 1.5em;
				    text-align: center;
				    z-index: 1;
				    font-weight: bold;
				    -webkit-box-shadow: 0 0 8px #444;
				    -moz-box-shadow: 0 0 8px #444;
				    box-shadow: 0 0 8px #444;
				    cursor: pointer;
				}

				.jr-objectbox-inner {
				    overflow: hidden;
				    position: absolute;
				    top: 0;
				    left:5;
				    right: 5;
				    bottom: 5;
				}

				.jr-objectbox-drawer {
				    width: 100%;
				    height: 100%;
				    overflow: auto;
				    -webkit-overflow-scrolling: touch;
				    position: static;
				    box-sizing: border-box;
				    background-color: #FFE;
				}

				/* article's content (figures/tables) in the object box */
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				    min-height: 100%;
				    box-sizing:  border-box;
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				.jr-objectbox article h3{
				    margin-top: 0;
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				.jr-objectbox article[data-type=fig] .figure {
				    text-align: center;
				    margin: 1em 0;
				}

				.jr-objectbox article img {
				    max-height: none;
				    border: 1px solid #444;
				}

				/* table */
				.jr-objectbox article[data-type=table-wrap] {
				    border: none;
				    padding: 1em;
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				.jr-objectbox article[data-type=fig] > div > div,
				.jr-objectbox article[data-type=fig] > div > h3,
				.jr-objectbox article[data-type=fig] > div > p,
				.jr-objectbox article[data-type=table-wrap] > div > div,
				.jr-objectbox article[data-type=table-wrap] > div > h3,
				.jr-objectbox article[data-type=table-wrap] > div > p{
				    max-width: 6in;
				    margin-left:auto;
				    margin-right:auto;
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				.jr-objectbox article[data-type=fig] > div > div.figure,
				.jr-objectbox article[data-type=table-wrap] > div > div.large_tbl {
					text-align:center;
				    max-width: none;
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				.jr-objectbox article[data-type=table-wrap] table {
				    margin-left:auto;
				    margin-right:auto;
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